a Record control number WOS:000347362000012

a ISSN 0065-1281

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number QU 300

b Item number .E97 2014

a Personal name Acar, Nuray.

h Medium Electronic Document

a Title Expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and peroxiredoxin 6 (Prdx6) proteins in healthy and pathologic placentas of human and rat

c Statement of responsibility, etc Nuray Acar, Hakan Soylu, Imren Edizer, Ozlem Ozbey, Hakan Er, Gokhan Akkoyunlu, Burcu Gemici, Ismail Ustunel.

a Place of publication, distribution, etc Elsevier ,

c Date of publication, distribution, etc 2014.

a Summary, etc A relationship has been shown between preeclampsia (PE) and intrauterine growth restriction (IUGR) and oxidative stress (OS). Since such pregnancies experience OS, we aimed to detect the distribution pattern and expression levels of a transcription factor, Nuclear factor erythroid 2-related factor-2 (Nrf2) that has a role in the regulation of antioxidant enzymes, and peroxiredoxin 6 (Prdx6) an antioxidant enzyme, in human healthy, IUGR, PE and in groups of rat healthy and IUGR placentas using immunohistochemistry and Western blotting. Both Nrf2 and Prdx6 immunoreactivities were weaker in human and rat IUGR group placentas compared to human and rat control group placentas, respectively. Nrf2 and Prdx6 were immunostained in labyrinth trophoblasts, decidua, giant, glycogen and fetal vessel endothelial cells in rat control and IUGR group placentas. Nrf2 and Prdx6 immunoreactivities were seen in the decidua, syncytiotrophoblasts, villous stromal cells, and vascular endothelium in human control, IUGR and PE group placentas. Results of Nrf2 and Prdx6 Western blotting applied for rat and human placentas were compatible with the results of Nrf2 and Prdx6 immunohistochemical observations with regard to rat and human placentas. Down-regulation of Nrf2 and Prdx6 proteins in human and rat IUGR group placentas may have led to the formation of OS which may have impaired proliferation and invasion of cytotrophoblasts. (C) 2014 Elsevier GmbH. All rights reserved.

a Topical term or geographic name as entry element Cell Biology

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Human

a Topical term or geographic name as entry element IUGR

a Topical term or geographic name as entry element Nrf2

a Topical term or geographic name as entry element Intrauterine Growth Restriction

g Relationship information 2014 , Vol 116 Issue 8, p1289-1300

x International Standard Serial Number 00651281

t Title Acta Histochemica

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1016/j.acthis.2014.07.012